4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]phenol

4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]phenol - Names and Identifiers

Name	4-(Tert-Butyldimethylsilyloxy)Phenol
Synonyms	4-(t-Butyldimethylsilyloxy)Phenol 4-(Tert-Butyldimethylsilyloxy)Phenol 4-[tert-butyl(dimethyl)silyl]oxyphenol 4-([tert-Butyl(dimethyl)silyl]oxy)phenol 4-{[tert-butyl(dimethyl)silyl]oxy}phenol 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]phenol Phenol, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-
CAS	108534-47-0
InChI	InChI=1/C12H20O2Si/c1-12(2,3)15(4,5)14-11-8-6-10(13)7-9-11/h6-9,13H,1-5H3

4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]phenol - Physico-chemical Properties

Molecular Formula	C12H20O2Si
Molar Mass	224.37
Density	0.974±0.06 g/cm3(Predicted)
Melting Point	60-64 °C (lit.)
Boling Point	266.4±23.0 °C(Predicted)
Flash Point	114.9°C
Vapor Presure	0.00526mmHg at 25°C
Appearance	Powder
Color	White to off-white
pKa	10.24±0.15(Predicted)
Storage Condition	Room Temprature
Sensitive	7: reacts slowly with moisture/water
Refractive Index	1.49
Physical and Chemical Properties	WGK Germany:3

4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]phenol - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	41 - Risk of serious damage to eyes
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection.
WGK Germany	3
TSCA	No

4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]phenol - Introduction

4-(tert-butyl dimethyl siloxy) phenol is also known as tert-butyl dimethyl siloxy phenol (TBDMS-Phenol), its nature, use, preparation and safety information are as follows:

Nature:
-Appearance: Colorless to light yellow liquid
-Molecular formula: C14H22O2Si
-Molecular weight: 250.42g/mol
-Solubility: Soluble in organic solvents such as chloroform, dimethylformamide and ether

Use:
-compound protecting group: TBDMS-Phenol can be used as a compound protecting group in chemical synthesis, which can protect hydroxyl groups in alcohol compounds to avoid unnecessary reactions and facilitate other chemical reactions.
-Organic synthesis: TBDMS-Phenol is widely used in organic synthesis and can be used to synthesize biologically active compounds.
-Chemical analysis: TBDMS-Phenol can be used for reagents and standards in organic chemical analysis.

Preparation Method:
-The preparation method of TBDMS-Phenol is generally obtained by reacting tert-butyl dimethyl chlorosilane with phenol. The specific steps include first subjecting tert-butyldimethylsilyl chloride and phenol to a condensation reaction under alkaline conditions to generate a TBDMS-Phenol product, which is then separated and purified to obtain the desired product.

Safety Information:
-The TBDMS-Phenol will not cause significant harm to the human body under normal operating conditions.
-As a chemical, follow laboratory safety procedures and personal protective measures.
- TBDMS-Phenol is a flammable liquid and should be kept away from open flames and high temperatures.
-Avoid contact with skin, eyes and respiratory tract during use. In case of contact, rinse immediately with plenty of water and seek medical help.
-Store sealed, away from fire and oxidizing agents.

Last Update：2024-04-10 22:29:15